function
histidine utilization
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.5|Utilization of histidine][SW|Categories] containing this gene/protein
[SW|utilization of amino acids]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|CodY regulon], [SW|HutP regulon]The protein
Catalyzed reaction/ biological activity
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O (according to Swiss-Prot)Protein family
urocanase family (according to Swiss-Prot)Structure
[PDB|2FKN][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|hutP]-[protein|search|hutH]-[protein|search|hutU]-[protein|search|hutI]-[protein|search|hutG]-[protein|search|hutM]'' [Pubmed|10746760][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8071225]Regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|8071225]induced by histidine ([protein|search|HutP]) [Pubmed|8071225]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8682780]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|8071225][protein|search|CodY]: transcription repression [Pubmed|8682780][protein|search|HutP]: transcriptional antitermination at a protein-dependent [SW|RNA switch] located between ''[protein|search|hutP]'' and ''[protein|search|hutH]'' [Pubmed|8071225]References
Reviews
Original publications
10746760,8071225,8682780,10217782,21821766 
