SubtiBank SubtiBank
hutU
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hutU

urocanase
Locus
BSU_39360
Isoelectric point
5.66
Molecular weight
60.43 kDa
Protein length
552 aa Sequence Blast
Gene length
1659 bp Sequence Blast
Function
histidine utilization
Product
urocanase
Essential
no
E.C.
4.2.1.49
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
4,043,574 → 4,045,232

The protein

Catalyzed reaction/ biological activity

  • 4-imidazolone-5-propanoate --> H2O + trans-urocanate (according to UniProt)
  • Protein family

  • urocanase family (single member, according to UniProt)
  • Structure

    Localization

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • CcpA: repression, PubMed, in CcpA regulon
  • CodY: repression, PubMed, in CodY regulon
  • HutP: antitermination, at a protein-dependent RNA switch located between hutP and hutH PubMed, in HutP regulon
  • Regulation

  • induced by histidine (HutP) PubMed
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    Biological materials

    Mutant

  • BKE39360 (ΔhutU::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_AGTCATATGTTCATCCCCCT, downstream forward: _UP4_ATGCAAAAATAAAGGAGTGA
  • BKK39360 (ΔhutU::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_AGTCATATGTTCATCCCCCT, downstream forward: _UP4_ATGCAAAAATAAAGGAGTGA
  • References

    Reviews

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    Original publications

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