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bmrA [2018-04-19 12:24:38]
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bmrA [2018-04-19 12:24:38]

multidrug ABC transporter (ATP-binding protein)
Locus
BSU34820
Isoelectric point
6.47
Molecular weight
64.34 kDa
Protein length
589 aa Sequence Blast
Gene length
1767 bp Sequence Blast
Function
multiple antibiotic resistance
Product
multidrug ABC transporter (ATP-binding protein)
Essential
no
Synonyms
yvcC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Transporters → ABC transporters → Exporters → Efflux of antibiotics
  • Lifestyles → Coping with stress → Resistance against toxins/ antibiotics
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    3,577,745 → 3,579,514

    The protein

    Paralogous protein(s)

  • YknU, YfiC, YwjA, YknV, YgaD, YfiB, BmrC

    • Domains

  • has both a membrane-spanning and an ATP-binding domain PubMed

    • Structure

  • 4AYT (human mitochondrial protein, 36% identity)

    • Localization

  • membrane PubMed

    • Expression and Regulation

    Operons

    Genes
    bmrA-yvcD
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulation

  • constitutively expressed PubMed

    • Additional information

  • half-life of the mRNA: 1.5 min PubMed
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    Biological materials

    Mutant

  • MGNA-B645 (yvcC::erm), available at the NBRP B. subtilis, Japan
  • BKE34820 (ΔbmrA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATATTTTCCTCCTGTTT, downstream forward: _UP4_TAAATTTTGGTCGAATCAGC
  • BKK34820 (ΔbmrA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATATTTTCCTCCTGTTT, downstream forward: _UP4_TAAATTTTGGTCGAATCAGC

    • References

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