bmrA [2017-8-11 16:0:3]

multidrug ABC transporter (ATP-binding protein)

locus: BSU34820

pI: 6.47

mw: 64.34 kDa

protein length: 589 aa

gene length: 1767 bp

function: multiple antibiotic resistance

product: multidrug ABC transporter (ATP-binding protein)

essential: no

synonyms: yvcC

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.1|Efflux of antibiotics]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 3,577,745 → 3,579,514

The protein

[SW|Domains]

• has both a membrane-spanning and an ATP-binding domain [Pubmed|10092453]

[SW|Localization]

• membrane [Pubmed|10092453]

Expression and Regulation

Operons

• genes: [gene|ED1F82463BAA28B67184BFAB5CB23CF26A62999D|bmrA]-[gene|EFF0635A4BBB62558A04BA49195D76234776F943|yvcD]
  description: [pubmed|22383849]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|21077936], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulation

  • constitutively expressed [Pubmed|21077936]

  additional information

  • half-life of the mRNA: 1.5 min [PubMed|21077936]

Biological materials

Mutant

• MGNA-B645 (yvcC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1644 NBRP B. subtilis, Japan]

References

• 16107340,15182191,15766260,16405427,12968023,10092453,18215075,12225846,20544182,11827477,21077936,21336797,21483854,27570617,28755379