heat-shock protein (activation of DnaK)
function
control of DnaK activity
product
heat-shock protein
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.2|Chaperones/ protein folding][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins][SW|Categories] containing this gene/protein
[SW|chaperones/ protein folding], [SW|heat shock proteins]This gene is a member of the following [SW|regulons]
[SW|HrcA regulon]Gene
Coordinates on the chromosome (coding sequence)
2,627,971 -> 2,628,534
The protein
Protein family
grpE family (according to Swiss-Prot)Structure
[PDB|4ANI] ([SW|DnaK]-[SW|GrpE] complex from ''Geobacillus kaustophilus'', 70% identity) [Pubmed|22544739][SW|Localization]
Cytoplasm (Homogeneous) [Pubmed|16479537]Expression and Regulation
Operon
''[protein|search|hrcA]-[protein|search|grpE]-[protein|search|dnaK]-[protein|search|dnaJ]-[protein|search|yqeT]-[protein|search|yqeU]-[protein|search|yqeV]'' [Pubmed|9023197][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1339421]Regulation
induced by heat shock ([protein|search|HrcA]) [Pubmed|1339421]Regulatory mechanism
[protein|search|HrcA]: transcription repression [Pubmed|1339421]Labs working on this gene/protein
[SW|Wolfgang Schumann], Bayreuth University, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/schumann_research.htm Homepage]References
10383760,9023197,1339421,16479537,1339421,7592421,22544739 
