function
glycerol utilization
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.3|Utilization of glycerol/ glycerol-3-phosphate][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|CcpA regulon], [SW|GlpP regulon]The protein
Catalyzed reaction/ biological activity
ATP + glycerol = ADP + sn-glycerol 3-phosphate (according to Swiss-Prot)Protein family
FGGY kinase family (according to Swiss-Prot)Structure
[PDB|3H46] (from ''Enterococcus casseliflavus'', complex with glycerol) [Pubmed|19102629][SW|Interactions]
[protein|search|PtsH]-[protein|search|GlpK]Expression and Regulation
Operon
''[protein|search|glpF]-[protein|search|glpK]'' [Pubmed|2127799][SW|Sigma factor]
[protein|search|SigA] [Pubmed|2127799]Regulation
repressed by glucose (8-fold) ([protein|search|CcpA]) [Pubmed|12850135]induction by glycerol ([protein|search|GlpP]) [Pubmed|8436953]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|12850135][protein|search|GlpP]-dependent [SW|RNA switch] (transcriptional antitermination) [Pubmed|8436953][protein|search|AbrB]: transcription activation [Pubmed|20817675]Biological materials
Mutant
BKE09290 (''glpK''::''ermC'') (available at the [http://www.bgsc.org/ BGSC] and in [SW|Jörg Stülke]'s lab)GP1865 (''glpK''::''ermC'') (available in [SW|Jörg Stülke]'s lab)Labs working on this gene/protein
[SW|Josef Deutscher], Paris-Grignon, FranceReferences
1335945,9162046,11929549,7773413,19102629,20817675 
