fhuG

hydroxamate siderophore ABC transporter (ferrichrome und ferrioxamine) (permease)

Locus: BSU_33300

Isoelectric point: 10.20

Molecular weight: 36.00 kDa

Protein length: 336 aa

Gene length: 1011 bp

Function: siderophore uptake

Product: hydroxamate siderophore ABC transporter (ferrichrome und ferrioxamine) (permease)

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → ABC transporters → Importers → Uptake of iron/ siderophores
• Cellular processes → Homeostasis → Acquisition of iron → ABC transporters for the uptake of iron/ siderophores
• Metabolism → Additional metabolic pathways → Iron metabolism → ABC transporters for the uptake of iron/ siderophores
• Groups of genes → Membrane proteins

Gene

Coordinates: 3,416,212 → 3,417,222

The protein

Protein family

• Binding-protein-dependent transport system permease family (according to UniProt)
• FecCD subfamily (according to UniProt)

Paralogous protein(s)

• FeuC, YfhA, FecE

Structure

• 4R9U, the E. coli BtuC-BtuD complex, BtuC shares 33% identity, 67% similarity with FhuG, PubMed

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: fhuB-fhuG-fhuC

  Description

  • PubMed

  Regulatory mechanism

  • Fur: repression, PubMed, in Fur regulon

  Regulation

  • induced by iron starvation (second wave to allow iron scavenging from the environment) (Fur) PubMed

Biological materials

Mutant

• BKE33300 (ΔfhuG::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CGGTTTGTTTGTTTTTGTTT, downstream forward: _UP4_GCGAATTAGAGGAGGGGGCC
• BKK33300 (ΔfhuG::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CGGTTTGTTTGTTTTTGTTT, downstream forward: _UP4_GCGAATTAGAGGAGGGGGCC

References

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