mutM [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

formamidopyrimidine-DNA glycosidase

Locus: BSU29080

Isoelectric point: 8.89

Molecular weight: 31.00 kDa

Function: DNA repair

Product: formamidopyrimidine-DNA glycosidase

Essential: no

E.C.: 3.2.2.23

Synonyms: ytaE

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → DNA repair/ recombination
• Information processing → Genetics → DNA repair/ recombination → Oxidized guanine (GO) DNA repair system

Categories containing this gene/protein

• DNA repair/ recombination

Gene

Coordinates on the chromosome (coding sequence): 2,972,329 -> 2,973,159

Phenotypes of a mutant

• increased susceptibility to Cr(VI) due to the accumulation of oxidative DNA damage PubMed
• absence of MutM promotes mutagenesis allowing nutritionally stressed B. subtilis cells to escape from growth limiting conditions PubMed
• increased sponteous mutation rate PubMed

The protein

Catalyzed reaction/ biological activity

• Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine (according to Swiss-Prot)

Protein family

• FPG family (according to Swiss-Prot)

Structure

• 2F5S (complex with oxoG:C, Geobacillus stearothermophilus)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Regulation

• expressed throughout exponential growth and stationary phase PubMed

References

Reviews

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Original publications

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