mutM [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

formamidopyrimidine-DNA glycosidase

locus: BSU29080

pI: 8.89

mw: 31.00 kDa

function: DNA repair

product: formamidopyrimidine-DNA glycosidase

essential: no

ec: 3.2.2.23

synonyms: ytaE

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.5|Oxidized guanine (GO) DNA repair system]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination]

Gene

Coordinates on the chromosome (coding sequence): 2,972,329 -> 2,973,159

Phenotypes of a mutant

• increased susceptibility to Cr(VI) due to the accumulation of oxidative DNA damage [Pubmed|24973075]
• absence of MutM promotes mutagenesis allowing nutritionally stressed ''B. subtilis'' cells to escape from growth limiting conditions [Pubmed|25825434]
• increased sponteous mutation rate [Pubmed|25825434]

The protein

Catalyzed reaction/ biological activity

• Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine (according to Swiss-Prot)

Protein family

• FPG family (according to Swiss-Prot)

Structure

• [PDB|2F5S] (complex with oxoG:C, Geobacillus stearothermophilus)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Regulation

• expressed throughout exponential growth and stationary phase [Pubmed|25825434]

References

Reviews

• 22933559

Original publications

• 19011023,19889642,24973075,25825434