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mutM [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]
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mutM [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

formamidopyrimidine-DNA glycosidase
Locus
BSU29080
Isoelectric point
8.89
Molecular weight
31.00 kDa
Function
DNA repair
Product
formamidopyrimidine-DNA glycosidase
Essential
no
E.C.
3.2.2.23
Synonyms
ytaE

Genomic Context

      
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Categories containing this gene/protein

Categories containing this gene/protein

Gene

Coordinates on the chromosome (coding sequence)
2,972,329 -> 2,973,159

Phenotypes of a mutant

  • increased susceptibility to Cr(VI) due to the accumulation of oxidative DNA damage PubMed
  • absence of MutM promotes mutagenesis allowing nutritionally stressed B. subtilis cells to escape from growth limiting conditions PubMed
  • increased sponteous mutation rate PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine (according to Swiss-Prot)
  • Protein family

  • FPG family (according to Swiss-Prot)
  • Structure

  • 2F5S (complex with oxoG:C, Geobacillus stearothermophilus)
  • Localization

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Regulation

  • expressed throughout exponential growth and stationary phase PubMed
  • References

    Reviews

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    Original publications

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