gmuE [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

mannose kinase

locus: BSU05860

pI: 5.01

mw: 32.00 kDa

function: glucomannan utilization

product: mannose kinase

essential: no

ec: 2.7.1.4

synonyms: ydhR

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.25|Utilization of glucomannan]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon], [SW|CcpA regulon], [SW|GmuR regulon]

Gene

Coordinates on the chromosome (coding sequence): 630,912 -> 631,811

The protein

Catalyzed reaction/ biological activity

• ATP + mannose = ADP + mannose 6-phosphate

Protein family

• ROK (nagC/xylR) family (according to Swiss-Prot)

Structure

• [PDB|1XC3] [Pubmed|21185308]

Expression and Regulation

Operon

• ''[protein|search|gmuB]-[protein|search|gmuA]-[protein|search|gmuC]-[protein|search|gmuD]-[protein|search|gmuR]-[protein|search|gmuE]-[protein|search|gmuF]-[protein|search|gmuG]'' [Pubmed|18177310]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|18177310]

Regulation

• induced by conjac glucomannan (requires [protein|search|GmuG]) ([protein|search|GmuR]) [Pubmed|18177310]
• induced by cellobiose ([protein|search|GmuR]) [Pubmed|18177310]
• subject to carbon catabolite repression ([protein|search|CcpA]) [Pubmed|18177310]

Regulatory mechanism

• [protein|search|GmuR]: transcription repression [Pubmed|18177310]
• [protein|search|CcpA]: transcription repression [Pubmed|18177310]
• [protein|search|AbrB]: transcription activation [Pubmed|20817675]

References

• 18177310,10627040,20817675,21185308