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btr [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]
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btr [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

transcriptional activator (AraC family), (AraC family DNA-binding domain fused to FeuA-like substrate-binding domain), regulation of the feuA-feuB-feuC-ybbA operon
locus
BSU01640
pI
6.43
mw
60.00 kDa
function
regulation of iron acquisition
product
transcription activator (AraC family)
essential
no
synonyms
ybbB, yzbC

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [SW|Categories] containing this gene/protein

  • [SW|acquisition of iron], [SW|iron metabolism], [SW|transcription factors and their control]
  • This gene is a member of the following [SW|regulons]

  • [SW|Fur regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    183,414 -> 185,003

    The protein

    Catalyzed reaction/ biological activity

  • binding of a direct repeat in the ''[protein|search|feuA]'' promoter region and transcription activation of the ''[protein|search|feuA]-[protein|search|feuB]-[protein|search|feuC]-[protein|search|ybbA]'' operon in the presence of bacillibactin or enterobactin [Pubmed|17725565,22210890]
  • Protein family

  • [SW|AraC family]
  • [SW|Cofactors]

  • enterobactin, bacillibactin (co-activators) [Pubmed|17725565]
  • Effectors of protein activity

  • enterobactin, bacillibactin (co-activators) [Pubmed|17725565]
  • [SW|Interactions]

  • [protein|search|Btr]-[SW|RNA polymerase] (perhaps [protein|search|SigA]) [Pubmed|22210890]
  • Expression and Regulation

    Operon

  • ''btr'' [Pubmed|12354229]
  • Regulation

  • expressed under conditions of iron starvation ([protein|search|Fur]) [Pubmed|12354229]
  • Regulatory mechanism

  • [protein|search|Fur]: transcription repression [Pubmed|12354229]
  • Additional information

  • the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
  • References

  • 12884008,17725565,22210890,12354229,23199363,23504016