transcriptional activator (AraC family), (AraC family DNA-binding domain fused to FeuA-like substrate-binding domain), regulation of the feuA-feuB-feuC-ybbA operon
function
regulation of iron acquisition
product
transcription activator (AraC family)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|acquisition of iron], [SW|iron metabolism], [SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|Fur regulon]Gene
Coordinates on the chromosome (coding sequence)
183,414 -> 185,003
The protein
Catalyzed reaction/ biological activity
binding of a direct repeat in the ''[protein|search|feuA]'' promoter region and transcription activation of the ''[protein|search|feuA]-[protein|search|feuB]-[protein|search|feuC]-[protein|search|ybbA]'' operon in the presence of bacillibactin or enterobactin [Pubmed|17725565,22210890]Protein family
[SW|AraC family][SW|Cofactors]
enterobactin, bacillibactin (co-activators) [Pubmed|17725565]Effectors of protein activity
enterobactin, bacillibactin (co-activators) [Pubmed|17725565][SW|Interactions]
[protein|search|Btr]-[SW|RNA polymerase] (perhaps [protein|search|SigA]) [Pubmed|22210890]Expression and Regulation
Operon
''btr'' [Pubmed|12354229]Regulation
expressed under conditions of iron starvation ([protein|search|Fur]) [Pubmed|12354229]Regulatory mechanism
[protein|search|Fur]: transcription repression [Pubmed|12354229]Additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]References
12884008,17725565,22210890,12354229,23199363,23504016