deoR [Fri Nov 13 2015 17:18:33 GMT+0100 (CET)]

transcriptional repressor of the dra-nupC-pdp operon

locus: BSU39430

pI: 6.00

mw: 35.00 kDa

function: regulation of deoxyribonucleotide utilization

product: transcriptional repressor

essential: no

synonyms: yxxC

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.1|Utilization of nucleotides]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

[SW|Categories] containing this gene/protein

• [SW|utilization of nucleotides], [SW|transcription factors and their control]

Gene

Coordinates on the chromosome (coding sequence): 4,052,379 -> 4,053,320

The protein

Catalyzed reaction/ biological activity

• transcription repression of the ''[protein|search|dra]-[protein|search|nupC]-[protein|search|pdp]'' operon

Protein family

• sorC transcriptional regulatory family (according to Swiss-Prot) DeoR family of transcription repressors

[SW|Domains]

• N-terminal DNA-binding domain [Pubmed|24863636]
• C-terminal effector binding domain [Pubmed|24863636]

Effectors of protein activity

• deoxyribose-5-phosphate acts as the molecular inducer [Pubmed|24863636]

Structure

• [http://pdb.org/pdb/explore/explore.do?structureId=4OQQ 4OQQ] (C-terminal effector binding domain) [Pubmed|24863636]
• [http://pdb.org/pdb/explore/explore.do?structureId=4OQP 4OQP] (C-terminal effector binding domain bound to the effector deoxyribose-5-phosphate ) [Pubmed|24863636]

Expression and Regulation

Operon

• ''deoR'' [Pubmed|10746760]

References

• 10714997,8550462,10074062,24863636