glpQ [Thu Oct 27 2016 11:12:11 GMT+0200 (CEST)]

glycerolphosphate diester phosphodiesterase, degrades wall teichoic acid during phosphate starvation

Locus: BSU02130

Isoelectric point: 9.00

Molecular weight: 32.00 kDa

Function: glycerol-3-phosphate utilization, degradation of wall teichoic acid during phosphate starvation

Product: glycerolphosphate diester phosphodiesterase

Essential: no

E.C.: 3.1.4.46

Synonyms: ybeD

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall degradation/ turnover → Utilization of cell wall components
• Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of glycerol/ glycerol-3-phosphate
• Metabolism → Lipid metabolism → Utilization of lipids → Utilization of phospholipids
• Metabolism → Additional metabolic pathways → Phosphate metabolism
• Groups of genes → Secreted proteins

Categories containing this gene/protein

• utilization of specific carbon sources, utilization of lipids

This gene is a member of the following regulons

• CcpA regulon, GlpP regulon, PhoP regulon

Gene

Coordinates on the chromosome (coding sequence): 233,014 -> 233,895

The protein

Catalyzed reaction/ biological activity

• exohydrolytic activity on wall teichoic acid, acts in concert with PhoD PubMed
• A glycerophosphodiester H₂O = an alcohol sn-glycerol 3-phosphate (according to Swiss-Prot)

Protein family

• glycerophosphoryl diester phosphodiesterase family (according to Swiss-Prot)

Paralogous protein(s)

• YhdW, YqiK

Structure

• 4R7O (the enzyme from Bacillus anthracis)
• 5T9B PubMed

Localization

• extracellular (signal peptide) PubMed

Expression and Regulation

Operon

• glpT-glpQ PubMed
• ''glpQ

Sigma factor

• SigA PubMed

Regulation

• repressed by glucose (6.2-fold) (CcpA) PubMed
• induced by glycerol (GlpP) PubMed
• glpQ: induced by phosphate limitation (PhoP) PubMed

Regulatory mechanism

• CcpA: transcription repression
• GlpP: transcriptional antitermination via a protein-dependent RNA switch
• PhoP: transcription activation PubMed

References

Reviews

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Original publications

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