glycerolphosphate diester phosphodiesterase, degrades wall teichoic acid during phosphate starvation
function
glycerol-3-phosphate utilization, degradation of wall teichoic acid during phosphate starvation
product
glycerolphosphate diester phosphodiesterase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.3|Utilization of cell wall components][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.3|Utilization of glycerol/ glycerol-3-phosphate][category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.1|Utilization of phospholipids][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.3|Phosphate metabolism][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|utilization of lipids]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|GlpP regulon], [SW|PhoP regulon]Gene
Coordinates on the chromosome (coding sequence)
233,014 -> 233,895
The protein
Catalyzed reaction/ biological activity
exohydrolytic activity on wall teichoic acid, acts in concert with [SW|PhoD] [Pubmed|27780866]A glycerophosphodiester H2O = an alcohol sn-glycerol 3-phosphate (according to Swiss-Prot) Protein family
glycerophosphoryl diester phosphodiesterase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YhdW], [protein|search|YqiK]Structure
[PDB|4R7O] (the enzyme from ''Bacillus anthracis'')[PDB|5T9B] [Pubmed|27780866][SW|Localization]
extracellular (signal peptide) [Pubmed|18957862]Expression and Regulation
Operon
''[protein|search|glpT]-[protein|search|glpQ]'' [Pubmed|8012593]''[protein|search|glpQ][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8012593]Regulation
repressed by glucose (6.2-fold) ([protein|search|CcpA]) [Pubmed|12850135]induced by glycerol ([protein|search|GlpP]) [Pubmed|8012593][protein|search|glpQ]: induced by phosphate limitation ([protein|search|PhoP]) [Pubmed|10913081]Regulatory mechanism
[protein|search|CcpA]: transcription repression[protein|search|GlpP]: transcriptional antitermination ''via'' a protein-dependent [SW|RNA switch][protein|search|PhoP]: transcription activation [Pubmed|10913081]References
Reviews
Original publications
8012593,10913081,18214974,18957862,27780866 
