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oatA [2020-05-08 10:15:45]
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oatA [2020-05-08 10:15:45]

O-acetyl transferase, provides resistance to lysozyme
locus
BSU_27140
pI
9.45
mw
72.04 kDa
protein length
634 aa Sequence Blast
gene length
1905 bp Sequence Blast
function
resistance to lysozyme
product
O-acetyl transferase
essential
no
synonyms
yrhL
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    2,771,318 → 2,773,222

    Phenotypes of a mutant

  • increased sensitivity to lysozyme [Pubmed|21856855]

    • The protein

    Protein family

  • Acyltransferase 3 family (with [protein|A408883503931320B1BC04F38E6D475530518A25|YfiQ] and [protein|07A53089107037359C428549FF877638B90CF074|YkrP], according to UniProt)

    • Structure

  • [PDB|6VJP] (from Staphylococcus aureus, C-terminal extracytoplasmic domain) [pubmed|32350117]

    • [SW|Localization]

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    genes
    [gene|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]-[gene|ED1DDA187692683D9862EC0E858B80CD56C48045|rsiV]-[gene|E97C7A219DB059BB634E893CC355A28324C87ADB|oatA]-[gene|FC37C7A0C0D9F50CA1D44B8D939CF06E210D4B38|yrhK]
    description
    [Pubmed|21856855]

    sigma factors

  • [protein|D04629D798E458AD538809BB2B150B7FA81D2C7E|SigV]: sigma factor, [Pubmed|21856855], in [regulon|D04629D798E458AD538809BB2B150B7FA81D2C7E|SigV regulon]

    • regulation

  • induced by lysozyme ([protein|search|SigV]) [Pubmed|21856855]

    • additional information

  • A [protein|search|ncRNA] ([SW|RnaC]) is encoded between '[protein|search|yrhK]' and '[protein|search|yrhJ]' [PubMed|25790031]
    • view in new tab

    Biological materials

    Mutant

  • MGNA-A146 (yrhL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/146 NBRP B. subtilis, Japan]
  • BKE27140 (Δ[gene|E97C7A219DB059BB634E893CC355A28324C87ADB|oatA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGGGTATTCCTCCAATAG, downstream forward: _UP4_TAAAAAAGAGATCCTATACA
  • BKK27140 (Δ[gene|E97C7A219DB059BB634E893CC355A28324C87ADB|oatA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGGGTATTCCTCCAATAG, downstream forward: _UP4_TAAAAAAGAGATCCTATACA

    • References

    Research papers

  • 32350117