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mrpA
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mrpA

Na+ transporter subunit of the Na+/H+ antiporter, multiple resistance and pH homeostasis
locus
BSU_31600
pI
9.52
mw
86.23 kDa
protein length
774 aa Sequence Blast
gene length
2325 bp Sequence Blast
function
sodium export
product
Na+/H+ antiporter subunit
essential
yes
synonyms
yufT,shaA,ntrA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.1|Metal ion homeostasis (K, Na, Ca, Mg)] → [category|SW 1.3.1.2|Sodium uptake/ export]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,246,679 → 3,249,003

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • a ''[gene|E968DECF869CAF7E247A518494AD70B554A7A25F|mrpA]'' mutant is viable at pH7.4 and sodium concentrations below 80 mM [Pubmed|24139955]
  • the ''[gene|E968DECF869CAF7E247A518494AD70B554A7A25F|mrpA]'' mutant accumulates internal sodium [Pubmed|24139955]

    • The protein

    Catalyzed reaction/ biological activity

  • Na transporter subunit of the Na /H antiporter [Pubmed|21236240]

    • Protein family

  • CPA3 antiporters (TC 2.A.63) subunit A family (single member, according to UniProt)

    • Structure

  • [PDB|4HE8] (from ''Thermus thermophilus'', 36% identity in a 57% fragment) [Pubmed|23417064]

    • [SW|Localization]

  • inner spore membrane [Pubmed|26731423]

    • Expression and Regulation

    Operons

    genes
    [gene|E968DECF869CAF7E247A518494AD70B554A7A25F|mrpA]-[gene|AAB15E7E3E3701AA3159370B85C151994244BA5B|mrpB]-[gene|D921139B18A665E9BB177C973FCF050A4BFFF97F|mrpC]-[gene|051D9BCC0CB05E39ED5825BB9BA77B8228EA055D|mrpD]-[gene|BF233467FAF95EEEE12A0D36C543DB357D8879EA|mrpE]-[gene|5CA2EA2D60FE4696903C16698C8329A20CBEBF72|mrpF]-[gene|B28796716C7E6C924F55176453DDBF9ADD0EF755|mrpG]
    description
    [Pubmed|9274030,10198001]
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    Biological materials

    Mutant

  • MGNA-B557 (yufT::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1556 NBRP B. subtilis, Japan]

    • References

    Reviews

  • 29218041

    • Original publications

  • 15019740,11004162,17693497,10198001,19389778,16730649,21236240,24021651,24095649,24139955,26731423,23417064,27391676,18408029