tagF

CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase

Locus: BSU_35720

Isoelectric point: 9.40

Molecular weight: 87.87 kDa

Protein length: 746 aa

Gene length: 2241 bp

Function: biosynthesis of teichoic acid

Product: CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase

Essential: yes

E.C.: 2.7.8.12

Synonyms: rodC

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of teichoic acid
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of teichoic acid
• Groups of genes → Essential genes
• Groups of genes → Membrane proteins

Gene

Coordinates: 3,676,159 → 3,678,399

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• 4-O-[(2R)-glycerylphospho]-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol --> 4-O-{[(2R)-1-glycerylphospho]_(n)-(2R)-1-glycerylphospho}-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H⁺ (according to UniProt)

Protein family

• CDP-glycerol glycerophosphotransferase family (with TagB, according to UniProt)

Structure

• 3L7I (C-terminal domain of the Staphylococcus epidermidis protein, 48% identity) PubMed

Localization

• membrane associated PubMed

Expression and Regulation

Operons

• Genes: tagD-tagE-tagF-tagG-tagH
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • PhoP: repression, PubMed, in PhoP regulon
  • WalR: activation, PubMed, in WalR regulon

  Regulation

  • repressed by phosphate (PhoP) PubMed

References

Reviews

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Original publications

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