hydroxamate siderophore ABC transporter (ATP-binding protein) (ferrichrome und ferrioxamine)
function
siderophore uptake
product
hydroxamate siderophore ABC transporter
(ATP-binding protein) (ferrichrome und ferrioxamine)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|acquisition of iron], [SW|iron metabolism], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|Fur regulon]The protein
Catalyzed reaction/ biological activity
ATP + H2O + iron chelate(Out) = ADP + phosphate + iron chelate(In) (according to Swiss-Prot)Structure
[PDB|4R9U], the ''E. coli'' BtuC-BtuD complex, BtuD shares 34% identity, 55% similarity with FhuC, [Pubmed|25402482][SW|Localization]
cell membrane (according to Swiss-Prot)[SW|Interactions]
[protein|search|FhuC]-([protein|search|FhuB]-[protein|search|FhuG])-([protein|search|FhuD]-[protein|search|YxeB]) [Pubmed|10092453]Expression and Regulation
Regulation
induced upon iron starvation ([protein|search|Fur]) [Pubmed|12354229]Regulatory mechanism
[protein|search|Fur]: transcription repression [Pubmed|12354229]References
10092453,16672620,25402482,12354229 
