SubtiBank SubtiBank
fhuC
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fhuC

hydroxamate siderophore ABC transporter (ATP-binding protein) (ferrichrome und ferrioxamine)
Locus
BSU_33290
Isoelectric point
6.50
Molecular weight
29.80 kDa
Protein length
269 aa Sequence Blast
Gene length
810 bp Sequence Blast
Function
siderophore uptake
Product
hydroxamate siderophore ABC transporter (ATP-binding protein) (ferrichrome und ferrioxamine)
Essential
no
E.C.
3.6.3.34
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Transporters → ABC transporters → Importers → Uptake of iron/ siderophores
  • Cellular processes → Homeostasis → Acquisition of iron → ABC transporters for the uptake of iron/ siderophores
  • Metabolism → Additional metabolic pathways → Iron metabolism → ABC transporters for the uptake of iron/ siderophores
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    3,415,387 → 3,416,196

    The protein

    Catalyzed reaction/ biological activity

  • ATP + H2O + Fe3+-hydroxamate complex-[hydroxamate-binding protein](Side 1) --> ADP + phosphate + Fe3+-hydroxamate complex(Side 2) + [hydroxamate-binding protein] (according to UniProt)

    • Protein family

  • ABC transporter superfamily (according to UniProt)

    • Paralogous protein(s)

  • FecF, YusV, FpbP

    • Domains

  • ABC transporter domain (aa 4-240) (according to UniProt)

    • Structure

  • 4R9U, the E. coli BtuC-BtuD complex, BtuD shares 34% identity, 55% similarity with FhuC, PubMed

    • Localization

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    Genes
    fhuB-fhuG-fhuC

    Description

  • PubMed

    • Regulatory mechanism

  • Fur: repression, PubMed, in Fur regulon

    • Regulation

  • induced by iron starvation (second wave to allow iron scavenging from the environment) (Fur) PubMed
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    Biological materials

    Mutant

  • BKE33290 (ΔfhuC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATTCGGCCCCCTCCTCT, downstream forward: _UP4_TGAAAAAATCCCGGTTTGAA
  • BKK33290 (ΔfhuC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATTCGGCCCCCTCCTCT, downstream forward: _UP4_TGAAAAAATCCCGGTTTGAA

    • References

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