lutR [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

transcriptional repressor (GntR family) of the lutA-lutB-lutC operon and of lutP

locus: BSU34180

pI: 4.85

mw: 19.00 kDa

function: control of lactate utilization

product: transcriptional repressor, (GntR family)

essential: no

synonyms: yvfI

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources], [SW|transcription factors and their control]

Gene

Coordinates on the chromosome (coding sequence): 3,509,831 -> 3,510,490

The protein

Catalyzed reaction/ biological activity

• transcriptional repressor of the'' [protein|search|lutA]-[protein|search|lutB]-[protein|search|lutC]'' operon [Pubmed|19201793]

Protein family

• [SW|GntR family] of transcription factors

Effectors of protein activity

• lactate acts as molecular inducer [Pubmed|19201793]

Expression and Regulation

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|25031425]

Biological materials

Mutant

• TEK1 lutR::Tn10::spc [Pubmed|24196425]

Expression vector

• pQE60-lutR (His-tag) [Pubmed|24196425]

lacZ fusion

• TEK7 lutR::lacZ::erm [Pubmed|24196425]

Labs working on this gene/protein

• [SW|Richard Losick], Harvard Univ., Cambridge, USA [http://www.mcb.harvard.edu/Losick/ homepage]
• [SW|Ayten Katatas], Istanbul Technical University, Istanbul, Turkey [http://www.bio.itu.edu.tr/personel_data/personel_ayten_yazgan_karatas.htm x]

References

• 24196425,19201793,25031425,18604637