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malP [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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malP [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

maltose-specific phosphotransferase system, EIICB of the PTS
locus
BSU08200
pI
8.87
mw
57.00 kDa
function
maltose uptake and phosphorylation
product
maltose-specific phosphotransferase system, EIICB
essential
no
ec
2.7.1.69
synonyms
glvC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.2|Phosphotransferase system] → [category|SW 1.2.2.2|Sugar specific PTS proteins]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.22|Utilization of maltose]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.3|Phosphorylation on a Cys residue]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

    • [SW|Categories] containing this gene/protein

  • [SW|phosphotransferase systems], [SW|utilization of specific carbon sources], [SW|membrane proteins], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|GlvR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    892,215 -> 893,798

    Phenotypes of a mutant

  • no growth on maltose as single carbon source [Pubmed|10627040]

    • The protein

    Catalyzed reaction/ biological activity

  • Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate (according to Swiss-Prot)

    • Protein family

  • [SW|PTS] permease, glucose permease (Glc) family [Pubmed|10627040]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|malA]-[protein|search|glvR]-[protein|search|malP]'' [Pubmed|11489864]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|11489864]

    • Regulation

  • induction by maltose ([protein|search|GlvR]) [Pubmed|11489864]
  • repressed by glucose ([protein|search|CcpA]) [Pubmed|11489864]

    • Regulatory mechanism

  • [protein|search|GlvR]: transcription activation [Pubmed|11489864]
  • [protein|search|CcpA]: transcription repression [Pubmed|11489864]

    • Biological materials

    Mutant

  • GP110 (spc), available in [SW|Stülke] lab

    • References

  • 16707683,10627040,11489864