yisP

farnesyl diphosphate phosphatase, production of farnesol

Locus: BSU_10810

Isoelectric point: 7.26

Molecular weight: 31.35 kDa

Protein length: 274 aa

Gene length: 825 bp

Function: control of KinC activity

Product: farnesyl diphosphate phosphatase

Essential: no

Synonyms: yucD

Genomic Context

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Categories containing this gene/protein

• Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of isoprenoids
• Information processing → Regulation of gene expression → phosphorelay
• Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation
• Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation → Other proteins required for biofilm formation
• Lifestyles → Sporulation → phosphorelay

Gene

Coordinates: 1,159,922 → 1,160,746

Phenotypes of a mutant

• complete loss of pellicle-forming ability PubMed
• reduced protein secretion PubMed

The protein

Catalyzed reaction/ biological activity

• farnesyl diphosphate -→ farnesol PubMed

Protein family

• phytoene/squalene synthase family (single member, according to UniProt)

Cofactors

• NADH PubMed

Structure

• 3WE9 PubMed

Expression and Regulation

Operons

• Genes: yisP
  Description: PubMed

  Sigma factors

  • SigB: sigma factor, PubMed, in SigB regulon

Biological materials

Mutant

• MGNA-B190 (yisP::erm), available at the NBRP B. subtilis, Japan
• BKE10810 (ΔyisP::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACTGCTTCTTCAAGTCTAG, downstream forward: _UP4_TAAAAAACACCCGGCCTTGA
• BKK10810 (ΔyisP::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACTGCTTCTTCAAGTCTAG, downstream forward: _UP4_TAAAAAACACCCGGCCTTGA

References

Reviews

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Original publications

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