tatAD

component of the TatAD-TatCD twin-arginine translocase

Locus: BSU_02630

Isoelectric point: 9.69

Molecular weight: 7.37 kDa

Protein length: 70 aa

Gene length: 213 bp

Function: TAT protein secretion

Product: component of the twin-arginine translocation pathway

Essential: no

Synonyms: yczB

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Phosphate metabolism
• Information processing → Protein synthesis, modification and degradation → Protein secretion
• Groups of genes → Membrane proteins

Gene

Coordinates: 285,775 → 285,987

The protein

Catalyzed reaction/ biological activity

• translocation of PhoD PubMed

Protein family

• TatA/E family (with TatAC and TatAY, according to UniProt)

Paralogous protein(s)

• TatAY, TatAC

Structure

• 2L16 PubMed

Localization

• membrane (according to Swiss-Prot), forms foci at the division sites and cell poles, localization requires interaction with TatCD or TatCY PubMed

Expression and Regulation

Operons

• Genes: phoD-tatAD-tatCD
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • PhoP: activation, PubMed, in PhoP regulon

  Regulation

  • expressed under conditions of phosphate limitation (PhoP) PubMed

  Additional information

  • expression of the operon depends on functional HemAT and CsbC PubMed

Biological materials

Mutant

• BKE02630 (ΔtatAD::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_GTTTGAAAACATAATTTCCA, downstream forward: _UP4_TGAATGCTGATGAGGCAGAC
• BKK02630 (ΔtatAD::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_GTTTGAAAACATAATTTCCA, downstream forward: _UP4_TGAATGCTGATGAGGCAGAC

Labs working on this gene/protein

• Jan Maarten van Dijl, University of Groningen, The Netherlands, Homepage

References

Reviews

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Original publications

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