bceB [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

ABC transporter (permease) for the export of bacitracin, plectasin, mersacidin and actagardine, sensory component of the Bce regulatory & detoxification system

Locus: BSU30370

Isoelectric point: 9.00

Molecular weight: 72.00 kDa

Function: export of toxic peptides

Product: bacitracin ABC transporter (permease)

Essential: no

Synonyms: ytsD

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → ABC transporters → Exporters → Export of peptides
• Lifestyles → Coping with stress → Resistance against toxins/ antibiotics
• Groups of genes → Membrane proteins

Categories containing this gene/protein

• ABC transporters, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

• BceR regulon

Gene

Coordinates on the chromosome (coding sequence): 3,109,397 -> 3,111,337

The protein

Catalyzed reaction/ biological activity

• binds bacitracin, K_D: 60 nM PubMed
• inhibits BceS autophosphorylation activity in the absence of bacitracin PubMed

Protein family

• ABC-4 integral membrane protein family (according to Swiss-Prot)

Effectors of protein activity

• the activity of the BceA-BceB ABC transporter is inhibited by heptaprenyl pyrophosphate which accumulates in a ytpB mutant PubMed

Localization

• cell membrane (according to Swiss-Prot)

Interactions

• BceA-BceB PubMed
• BceB-BceS, in the absence of bacitracin PubMed

Expression and Regulation

Operon

• bceA-bceB PubMed

Regulation

• induced in the presence of bacitracin, plectasin, mersacidin and actagardine (BceR) PubMed

Regulatory mechanism

• BceR: transcription activation PubMed

References

Reviews

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Original publications

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