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bceB [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]
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bceB [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

ABC transporter (permease) for the export of bacitracin, plectasin, mersacidin and actagardine, sensory component of the Bce regulatory & detoxification system
locus
BSU30370
pI
9.00
mw
72.00 kDa
function
export of toxic peptides
product
bacitracin ABC transporter (permease)
essential
no
synonyms
ytsD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.3|Export of peptides]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|BceR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,109,397 -> 3,111,337

    The protein

    Catalyzed reaction/ biological activity

  • binds bacitracin, KD: 60 nM [Pubmed|25118291]
  • inhibits [protein|search|BceS] autophosphorylation activity in the absence of bacitracin [Pubmed|25118291]

    • Protein family

  • ABC-4 integral membrane protein family (according to Swiss-Prot)

    • Effectors of protein activity

  • the activity of the [protein|search|BceA]-[protein|search|BceB] [SW|ABC transporter] is inhibited by heptaprenyl pyrophosphate which accumulates in a ''[protein|search|ytpB]'' mutant [Pubmed|24806199]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • [SW|Interactions]

  • [protein|search|BceA]-[protein|search|BceB] [Pubmed|25118291,23687272]
  • [protein|search|BceB]-[protein|search|BceS], in the absence of bacitracin [Pubmed|25118291,23687272,21283517]

    • Expression and Regulation

    Operon

  • ''[protein|search|bceA]-[protein|search|bceB]'' [Pubmed|12890034]

    • Regulation

  • induced in the presence of bacitracin, plectasin, mersacidin and actagardine ([protein|search|BceR]) [Pubmed|12890034]

    • Regulatory mechanism

  • [protein|search|BceR]: transcription activation [Pubmed|12890034]

    • Biological materials

    Mutant

  • MGNA-A168 (ytsD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/168 NBRP B. subtilis, Japan]

    • References

    Reviews

  • 27344142

    • Original publications

  • 18394148,17905982,12890034,14651641,10092453,14612242,21283517,20606066,21078927,23687272,25118291,24806199,26199330