yydH

membrane protease, processing of modified YydF

Locus: BSU_40160

Isoelectric point: 9.64

Molecular weight: 29.72 kDa

Protein length: 252 aa

Gene length: 759 bp

Function: control of LiaR-LiaS activity

Product: membrane protease

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Miscellaneous metabolic pathways → Biosynthesis of antibacterial compounds
• Information processing → Protein synthesis, modification and degradation → Proteolysis → Additional proteins involved in proteolysis
• Information processing → Regulation of gene expression → Transcription factors and their control → Control of two-component response regulators → Control of response regulators/ other
• Lifestyles → Coping with stress → Biosynthesis of antibacterial compounds
• Groups of genes → Membrane proteins

Gene

Coordinates: 4,125,742 → 4,126,500

The protein

Catalyzed reaction/ biological activity

• processing of modified YydF, results in mature peptide (residues 33-49) PubMed

Protein family

• peptidase M50B family (according to UniProt)

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: yydF-yydG-yydH-yydI-yydJ
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • AbrB: repression, PubMed, in AbrB regulon
  • Rok: repression, PubMed, in Rok regulon

  Regulation

  • activated after transition to stationary phase(AbrB) PubMed

Biological materials

Mutant

• MGNA-B809 (yydH::erm), available at the NBRP B. subtilis, Japan
• BKE40160 (ΔyydH::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CTTCATACTTTAAAATTTTC, downstream forward: _UP4_TAGAGTAAAAGATCTCCAAA
• BKK40160 (ΔyydH::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CTTCATACTTTAAAATTTTC, downstream forward: _UP4_TAGAGTAAAAGATCTCCAAA

References

Reviews

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Original publications

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