5-methylthioribose kinase
function
methionine salvage
product
5-methylthioribose kinase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins], [SW|phosphoproteins], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|S-box]Gene
Coordinates on the chromosome (coding sequence)
1,423,241 -> 1,424,440
The protein
Catalyzed reaction/ biological activity
ATP S-methyl-5-thio-D-ribose = ADP S-methyl-5-thio-alpha-D-ribose 1-phosphate (according to Swiss-Prot)Protein family
methylthioribose kinase family (according to Swiss-Prot)Modification
phosphorylated on Arg-80 OR Arg-82 and Arg-365 [Pubmed|22517742]Structure
[PDB|2PUP][SW|Localization]
membrane associated [Pubmed|18763711]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]Expression and Regulation
Operon
''[protein|search|mtnK]-[protein|search|mtnA]'' [Pubmed|11545674][SW|Sigma factor]
[protein|search|SigA] [Pubmed|12022921]Regulation
induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]Regulatory mechanism
[protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]References
12022921,10094622,11914366,11545674,15102328,18763711,12787499,18039762,22517742,23649237,15378759 
