tagV [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

phosphotransferase, attaches teichoic acid, teichuronic acid, or acidic capsular polysaccharide to cell wall peptidoglycan via phosphodiester linkage to N-acteylmuramic acid

locus: BSU35520

pI: 9.14

mw: 43.00 kDa

function: transfer of anionic cell wall polymers from lipid-linked precursors to peptidoglycan

product: phosphotransferase, responsible for attachment of anionic polymers to peptidoglycan

essential: no

synonyms: yvhJ

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.6|Export of anionic polymers and attachment to peptidoglycan]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|cell wall synthesis], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|Spo0A regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,647,406 -> 3,648,581

Phenotypes of a mutant

• a ''[protein|search|tagV]'' mutant has no phenoype, the triple ''[protein|search|tagT] [protein|search|tagU] [protein|search|tagV]'' mutant is unable to grow under normal conditions [Pubmed|21964069]

The protein

Protein family

• LytR-Cps2a-Psr family [Pubmed|19099556]

Paralogous protein(s)

• [protein|search|TagT], [protein|search|TagU]

[SW|Cofactors]

• Mg(2+) [Pubmed|21964069]

Structure

• [PDB|3NXH]

[SW|Localization]

• cytoplasmic membrane (with extracytoplasmic catalaytic domain) [Pubmed|21964069]

Expression and Regulation

Operon

• ''[protein|search|yvyE]-[protein|search|tagV]'' [Pubmed|22383849]

Regulation

• repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]

Regulatory mechanism

• [SW|Spo0A]: transcription repression [Pubmed|14651647]

References

Reviews

• 24024634

Original publications

• 14651647,19099556,21964069,22383849