ftsX [Mon Aug 31 2015 13:57:03 GMT+0200 (CEST)]

ABC transporter (membrane protein) (FtsE-FtsX), required for CwlO activity (cell elongation) and for proper activation of Spo0A and initiation of sporulation

Locus: BSU35250

Isoelectric point: 10.02

Molecular weight: 32.00 kDa

Function: control of cell wall synthesis

Product: ABC transporter (membrane protein)

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Autolytic activity required for peptidoglycan synthesis (cell elongation)
• Cellular processes → Transporters → ABC transporters → Regulatory ABC transporters
• Information processing → Regulation of gene expression → phosphorelay
• Lifestyles → Sporulation → phosphorelay
• Groups of genes → Membrane proteins

Categories containing this gene/protein

• ABC transporters, cell wall synthesis, phosphorelay, membrane proteins

This gene is a member of the following regulons

• Spo0A regulon

Gene

Phenotypes of a mutant

• a ftsX mutation is synthetically lethal with a lytE mutation (due to a lack of autolysin activity) PubMed
• shorter, fatter cells, this can be rescued by addition of Mg(2+) PubMed
• reduced growth rate, especially at low Mg(2+) concentrations PubMed

The protein

Catalyzed reaction/ biological activity

• necessary for the autolysin activity of CwlO PubMed

Protein family

• FtsX subfamily (according to Swiss-Prot)

Localization

• cell membrane PubMed

Interactions

• FtsE-FtsX PubMed
• FloT-FtsX PubMed
• FtsX-CwlO, at the membrane PubMed

Expression and Regulation

Operon

• ftsE-ftsX (according to DBTBS)

Regulation

• repressed under conditions that trigger sporulation (Spo0A) PubMed

Regulatory mechanism

• Spo0A: transcription repression PubMed

References

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