ytaG [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

dephospho-CoA kinase

locus: BSU29060

pI: 4.86

mw: 21.00 kDa

function: synthesis of coenzyme A

product: dephospho-CoA kinase

essential: yes

ec: 2.7.1.24

synonyms: coaE

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.4|Biosynthesis of coenzyme A]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors], [SW|essential genes], [SW|phosphoproteins], [SW|sporulation proteins]

Gene

Coordinates on the chromosome (coding sequence): 2,970,922 -> 2,971,515

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• ATP + 3'-dephospho-CoA = ADP + CoA (according to Swiss-Prot)

Protein family

• coaE family (according to Swiss-Prot)

Modification

• phosphorylated on ser/ thr/ tyr [Pubmed|16493705]

Structure

• [PDB|1N3B] (from ''Escherichia coli'', 40% identity, 60% similarity) [Pubmed|12538896]

Expression and Regulation

Operon

• ''[protein|search|ytaG]'' [Pubmed|9387221]

References

• 16493705,9387221,11292795,12538896