mtrB [Sun Nov 06 2016 18:27:07 GMT+0100 (CET)]

tryptophan operon RNA-binding attenuation protein (TRAP), controls the RNA switch in front of genes involved in biosynthesis and acquisition of tryptophan

locus: BSU22770

pI: 7.00

mw: 8.00 kDa

function: regulation of tryptophan biosynthesis
(and translation) attenuation in the trp operon;
repression of the folate operon

product: tryptophan operon RNA-binding attenuation protein (TRAP)

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.4|RNA binding regulators]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids], [SW|transcription factors and their control], [SW|RNA binding regulators]

Gene

Coordinates on the chromosome (coding sequence): 2,384,534 -> 2,384,761

The protein

Protein family

• prpD family (according to Swiss-Prot)

Effectors of protein activity

• binding of tryptophan results RNA binding and thus in transcription termination

Structure

• [PDB|3AQD], [PDB|1WAP] (complex with L-tryptophan), [PDB|2ZP9] (complex with [protein|search|RtpA])

[SW|Interactions]

• forms 11-mers
• [MtrB|search|TRAP]₁₁-[protein|search|RtpA]₃ [Pubmed|24682818,11557884]

Expression and Regulation

Operon

• ''[protein|search|folE]-[protein|search|mtrB]'' [Pubmed|2123343]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|2123343]

References

Reviews

• 19385727,16285852,15063849

Original Publications

• 22970197,19033375,17881743,10660627,10714985,12963367,14702295,16879415,17114058,17114263,11805104,7525975,10735881,15262953,14976255,8647825,18334255,10499579,7715723,8932308,11214184,15743934,7515880,9242649,7759487,15050822,14687568,9245598,9765233,11914485,15099736,7678334,8643393,15588817,16738132,1551827,17555767,7544009,11786553,11566976,2123343,11557884,12133840,16784236,10369778,7715723,10499579,11566976,7515880,21097886,21984911,24505391,24572018,24682818,25579595,27812824