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tuaD [Thu Mar 03 2016 09:28:17 GMT+0100 (CET)]
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tuaD [Thu Mar 03 2016 09:28:17 GMT+0100 (CET)]

UDP glucose 6-dehydrogenase
locus
BSU35580
pI
6.00
mw
49.00 kDa
function
biosynthesis of teichuronic acid
product
UDP glucose 6-dehydrogenase
essential
no
ec
1.1.1.22
synonyms
yvhD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.5|Biosynthesis of teichuronic acid]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.4|Biosynthesis of teichuronic acid]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.7|Phosphorylation on a Tyr residue]

    • [SW|Categories] containing this gene/protein

  • [SW|cell wall synthesis], [SW|biosynthesis of cell wall components]

    • This gene is a member of the following [SW|regulons]

  • [SW|PhoP regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,654,139 -> 3,655,524

    The protein

    Catalyzed reaction/ biological activity

  • UDP-glucose 2 NAD H2O = UDP-glucuronate 2 NADH (according to Swiss-Prot)

    • Protein family

  • UDP-glucose/GDP-mannose dehydrogenase family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|YtcA], [protein|search|Ugd]

    • Modification

  • phosphorylation on a Tyr residue by [protein|search|PtkA] [Pubmed|12970183], dephosphorylated by [protein|search|PtpZ] [Pubmed|15866923]

    • Effectors of protein activity

  • [protein|search|PtkA]-dependent phosphorylation stimulates TuaD activity [Pubmed|12970183]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|tuaA]-[protein|search|tuaB]-[protein|search|tuaC]-[protein|search|tuaD]-[protein|search|tuaE]-[protein|search|tuaF]-[protein|search|tuaG]-[protein|search|tuaH]'' [Pubmed|10048024]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|10048024]

    • Regulation

  • expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|9611818,10627039]

    • Regulatory mechanism

  • [protein|search|PhoP]: transcription activation [Pubmed|9611818,10627039]

    • References

  • 10913081,10376820,9611818,12970183,10048024,10627039,15866923