excinuclease ABC (subunit B), required for transcription-dependent asymmetry in mutation rates of genes in the two orientations
function
DNA repair after UV damage
product
excinuclease ABC (subunit B)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination]This gene is a member of the following [SW|regulons]
[SW|LexA regulon]The protein
Protein family
uvrB family (according to Swiss-Prot)Structure
[PDB|2NMV] (bound to fluorescein-adducted DNA); [PDB|2D7D] ternary complex involving UvrB* (a C-terminal truncation of full-length UvrB), a polythymine trinucleotide and ADP [Pubmed|16426634][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|UvrA]-[protein|search|UvrB] [Pubmed|16464004][protein|search|UvrB]-[protein|search|UvrC] [Pubmed|16464004][protein|search|UvrB] interacts sequentially with [protein|search|UvrA] and [protein|search|UvrC], a complex of the three proteins was never observed [Pubmed|16464004][protein|search|UvrB]-[protein|search|PcrA] [Pubmed|24147116]Expression and Regulation
Operon
''[protein|search|uvrB]-[protein|search|uvrA]'' (according to [http://dbtbs.hgc.jp/COG/prom/uvrBA.html DBTBS])Regulation
induced upon DNA damage ([protein|search|LexA]) [Pubmed|8226626]Regulatory mechanism
[protein|search|LexA]: transcription repression [Pubmed|8226626]Biological materials
Mutant
GP1175 (del ''uvrAB''::''ermC'') (available in the [SW|Stülke] lab)References
Reviews
16464004,15927210,7801120,22933559 Original publications
8226626,9555905,16426634,21821766,24147116,21145481,25713353 
