SubtiBank SubtiBank
albA
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albA

radical S-adenosylmethionine enzyme, antilisterial bacteriocin (subtilosin) production
Locus
BSU_37370
Isoelectric point
6.20
Molecular weight
51.35 kDa
Protein length
448 aa Sequence Blast
Gene length
1347 bp Sequence Blast
Function
antilisterial bacteriocin (subtilosin) production
Product
radical S-adenosylmethionine enzyme
Essential
no
Synonyms
ywiA

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
3,836,323 → 3,837,669

The protein

Catalyzed reaction/ biological activity

  • catalyzes thioether bond formation in subtilosin A PubMed
  • Cofactors

  • contains two Fe-S clusters PubMed
  • Structure

  • 6EFN (SkfB,corresponds to aa 109 ... 382, 32% identity) PubMed
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • Rok: repression, PubMed, in Rok regulon
  • ResD: activation, PubMed, in ResD regulon
  • AbrB: repression, PubMed, in AbrB regulon
  • Regulation

  • expressed under anaerobic conditions (ResD) PubMed
  • expression of the operon is strongly induced at the beginning of biofilm formation PubMed
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    Biological materials

    Mutant

  • MGNA-B263 (ywiA::erm), available at the NBRP B. subtilis, Japan
  • BKE37370 (ΔalbA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAAATACCATCCCCTATAC, downstream forward: _UP4_CAGCTTATTTAGGAGGGAAA
  • BKK37370 (ΔalbA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAAATACCATCCCCTATAC, downstream forward: _UP4_CAGCTTATTTAGGAGGGAAA
  • References

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