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hisH [Tue Oct 25 2016 16:58:42 GMT+0200 (CEST)]
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hisH [Tue Oct 25 2016 16:58:42 GMT+0200 (CEST)]

imidazole glycerol phosphate synthase (glutaminase subunit)
locus
BSU34890
pI
5.00
mw
23.00 kDa
function
biosynthesis of histidine
product
imidazole glycerol phosphate synthase (glutaminase subunit)
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,585,051 -> 3,585,689

    The protein

    Catalyzed reaction/ biological activity

  • 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide L-glutamine = imidazole-glycerol phosphate 5-aminoimidazol-4-carboxamide ribonucleotide L-glutamate H2O (according to Swiss-Prot)

    • Structure

  • [PDB|1KA9] (the [SW|HisF]-[SW|HisH] complex from ''Thermus thermophilus'', 39% identity) [Pubmed|12417026]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • [SW|Interactions]

  • [SW|HisF]-[SW|HisH] [Pubmed|12417026]

    • Expression and Regulation

    Operon

  • ''[protein|search|hisZ]-[protein|search|hisG]-[protein|search|hisD]-[protein|search|hisB]-[protein|search|hisH]-[protein|search|hisA]-[protein|search|hisF]-[protein|search|hisI]'' [Pubmed|12107147]

    • Regulation

  • repressed by casamino acids [Pubmed|12107147]

    • References

    Reviews

  • 12859215

    • Original publications

  • 3106153,12107147,12417026