pssA

phosphatidylserine synthase

Locus: BSU_02270

Isoelectric point: 7.88

Molecular weight: 19.47 kDa

Protein length: 177 aa

Gene length: 534 bp

Function: biosynthesis of phospholipids

Product: phosphatidylserine synthase

Essential: no

E.C.: 2.7.8.8

Synonyms: pss

Genomic Context

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Categories containing this gene/protein

• Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of phospholipids
• Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)
• Groups of genes → Membrane proteins

Gene

Coordinates: 247,744 → 248,277

The protein

Catalyzed reaction/ biological activity

• CDP-1,2-diacyl-sn-glycerol + L-serine --> 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H⁺ (according to UniProt)

Protein family

• CDP-alcohol phosphatidyltransferase class-I family (with PgsA, according to UniProt)

Localization

• cell membrane at the septum PubMed

Expression and Regulation

Operons

• Genes: ybfK-pssA-ybfM-psd
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigX: sigma factor, PubMed, in SigX regulon

Biological materials

Mutant

• BKE02270 (ΔpssA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACAGTGTAACCAAACCTCC, downstream forward: _UP4_GCAGAAAACCTGGAGTCTGG
• BKK02270 (ΔpssA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACAGTGTAACCAAACCTCC, downstream forward: _UP4_GCAGAAAACCTGGAGTCTGG

References

Reviews

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Original publications

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