methionyl-tRNA synthetase
product
methionyl-tRNA synthetase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
45,633 -> 47,627
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP L-methionine tRNA(Met) = AMP diphosphate L-methionyl-tRNA(Met) (according to Swiss-Prot) Protein family
tRNA-binding domain (according to Swiss-Prot)Modification
phosphorylated on Ser-652 [Pubmed|20509597]Structure
[PDB|1WE0] (from ''Thermus thermophilus hb8 mutant'', 40% identity, 57% similarity) [Pubmed|10673435][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''metSRegulation
repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647]Additional information
the terminator is [protein|search|NusA]-dependent [ http://www.nature.com/articles/nmicrobiol20157 Reference]References
