cheC [Mon Aug 31 2015 13:54:20 GMT+0200 (CEST)]

control of chemotaxis by interacting with CheD, CheY-P phosphatase, inhibition of CheR-mediated methylation of MCPs

locus: BSU16450

pI: 4.04

mw: 22.00 kDa

function: motility and chemotaxis

product: CheY-P phosphatase

essential: no

synonyms: ylxJ

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.4|Protein phosphatases]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.1|Soluble signalling proteins]

syns: ylxJ

[SW|Categories] containing this gene/protein

• [SW|protein modification], [SW|motility and chemotaxis]

This gene is a member of the following [SW|regulons]

• [SW|CodY regulon], [SW|DegU regulon], [SW|SigD regulon], [SW|Spo0A regulon]

The protein

Catalyzed reaction/ biological activity

• [protein|search|CheY]-P phosphatase
• controls binding of [protein|search|CheD] to chemoreceptors in response to the levels of [protein|search|CheY]-P [Pubmed|23226535]

Protein family

• cheC family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|FliY]

Effectors of protein activity

• interaction with [protein|search|CheD] enhances phosphatase activity towards [protein|search|CheY]-P [Pubmed|17908686]

[SW|Interactions]

• [protein|search|McpB]-[protein|search|CheC] [Pubmed|11722727]
• [protein|search|CheA]-[protein|search|CheC] [Pubmed|11722727]
• [protein|search|CheC]-[protein|search|CheD] [Pubmed|17908686], this interaction is enhanced by [protein|search|CheY]-P [Pubmed|23226535]
• [protein|search|CheC]-[protein|search|CheY]-P

Expression and Regulation

Operon

• part of the [[fla-che operon]]
• ''[protein|search|flgB]-[protein|search|flgC]-[protein|search|fliE]-[protein|search|fliF]-[protein|search|fliG]-[protein|search|fliH]-[protein|search|fliI]-[protein|search|fliJ]-[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|9657996,8157612,15175317]
• ''[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|20233303]

[SW|Sigma factor]

• ''[protein|search|flgB]'': [protein|search|SigA] [Pubmed|9657996], [protein|search|SigD] [Pubmed|9657996]
• ''[protein|search|ylxF]'': [protein|search|SigD] [Pubmed|20233303]

Regulation

• see [[fla-che operon]]

Regulatory mechanism

• see [[fla-che operon]]

Biological materials

Mutant

• 1A862 (no resistance), [Pubmed|7893679], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A862&Search=1A862 BGSC]
• DS6867 (marker-less in NCIB3610) [Pubmed|25313396]

References

• 25313396,7893679,14993307,18774298,8866475,18990184,17908686,14749334,11722727,9194713,14651647,9657996,8157612,15175317,17609139,16469702,20080618,17675386,20133180,17850253,21515776,23226535,24386445