ung [Fri Aug 19 2016 12:27:58 GMT+0200 (CEST)]

uracil-DNA glycosylase

locus: BSU37970

pI: 8.00

mw: 25.00 kDa

function: DNA repair

product: uracil-DNA glycosylase

essential: no

synonyms: ipa-57d, ywdG

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination]

Gene

Coordinates on the chromosome (coding sequence): 3,897,685 -> 3,898,362

Phenotypes of a mutant

• increased mutation rates [Pubmed|22056936]

The protein

Catalyzed reaction/ biological activity

• removes uracil preferentially from single-stranded DNA over double-stranded DNA, exhibiting higher preference for U:G than U:A mismatches [Pubmed|21542855]

Protein family

• uracil-DNA glycosylase family (according to Swiss-Prot)

Structure

• [PDB|3A7N] (from ''Mycobacterium tuberculosis'', 42% identity) [Pubmed|20693660]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

[SW|Interactions]

• [protein|search|SsbA]-[protein|search|Ung] [Pubmed|21170359]

Expression and Regulation

Operon

• ''ung'' [Pubmed|9353933]

Regulation

• expressed throughout growth and staionary phase [Pubmed|22056936]

References

Reviews

• 22933559

Original publications

• 9353933,20693660,22056936,21170359,21542855,25326311