treR [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

transcription repressor of the treP-treA-treR operon (GntR family)

locus: BSU07820

pI: 6.82

mw: 27.00 kDa

function: regulation of trehalose utilization

product: transcription repressor (GntR family)

essential: no

synonyms: yfxA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.20|Utilization of trehalose]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources], [SW|transcription factors and their control]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon], [SW|PhoP regulon], [SW|TreR regulon]

Gene

Coordinates on the chromosome (coding sequence): 853,556 -> 854,272

The protein

Protein family

• [SW|GntR family] of transcription factors

Structure

• [PDB|2OGG] (effector binding domain) [Pubmed|17705272]

Expression and Regulation

Operon

• ''[protein|search|treP]-[protein|search|treA]-[protein|search|treR]'' [Pubmed|8755887]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8755887]

Regulation

• induced by trehalose ([protein|search|TreR]) [Pubmed|8755887]
• repressed by glucose ([protein|search|CcpA]) [Pubmed|18977770]
• expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|21636651]

Regulatory mechanism

• [protein|search|TreR]: transcription repression [Pubmed|8755887]
• [protein|search|CcpA]: transcription repression [Pubmed|18977770]
• [protein|search|PhoP]: transcription activation [Pubmed|21636651]

References

• 8755887,9829827,8917076,17705272,18977770