SubtiBank SubtiBank
bdbA
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bdbA

thiol-disulfide oxidoreductase
Locus
BSU_21460
Isoelectric point
8.34
Molecular weight
16.04 kDa
Protein length
137 aa Sequence Blast
Gene length
414 bp Sequence Blast
Function
oxidative folding of proteins
Product
thiol-disulfide oxidoreductase
Essential
no
Synonyms
yolI

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
2,266,936 → 2,267,349

The protein

Protein family

  • Thioredoxin family (according to UniProt)
  • Domains

  • Thioredoxin domain (aa 26-136) (according to UniProt)
  • Localization

  • secreted (according to UniProt)
  • Expression and Regulation

    Operons

    Description

    Regulatory mechanism

  • Rok: repression, PubMed, in Rok regulon
  • Abh: activation, PubMed, in Abh regulon
  • DnaA: repression, Rok-DnaA PubMed, in DnaA regulon
  • YvrHb: activation, PubMed, in YvrHb regulon
  • AbrB: repression, PubMed, in AbrB regulon
  • Regulation

  • repressed by Rok-DnaA PubMed
  • expression starts in the stationary phase PubMed
  • expression is heterogeneous in the population, this is mediated by AbrB, Rok, and Spo0A PubMed
  • Additional information

  • the mRNA is very stable (> 15 min) PubMed
  • the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed
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    Biological materials

    Mutant

  • BKE21460 (ΔbdbA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TTTCATATAGAATACTCCTT, downstream forward: _UP4_TTTGATAAAAATGGTGATAG
  • BKK21460 (ΔbdbA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TTTCATATAGAATACTCCTT, downstream forward: _UP4_TTTGATAAAAATGGTGATAG
  • References

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