arsC [Mon Aug 31 2015 13:55:44 GMT+0200 (CEST)]

arsenate reductase

locus: BSU25780

pI: 4.75

mw: 15.00 kDa

function: detoxification of arsenate

product: arsenate reductase

essential: no

ec: 3.1.3.48

synonyms: yqcM

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.11|Resistance against toxic metals]
• [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.3|Skin element]

syns: yqcM

[SW|Categories] containing this gene/protein

• [SW|resistance against toxic metals], [SW|Skin element]

This gene is a member of the following [SW|regulons]

• [SW|ArsR regulon], [SW|SigF regulon]

The protein

Catalyzed reaction/ biological activity

• Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate (according to Swiss-Prot)

Protein family

• ArsC family (according to Swiss-Prot)

Structure

• [PDB|1Z2D] (reduced form), [PDB|1Z2E] (oxidized form), [PDB|2IPA] (TrxA-ArsC-complex) [Pubmed|17303556], [PDB|1JL3]

[SW|Interactions]

• [protein|search|ArsC]-[protein|search|TrxA] [Pubmed|17303556]

Expression and Regulation

Operon

• ''[protein|search|arsR]-[protein|search|yqcK]-[protein|search|arsB]-[protein|search|arsC]'' [Pubmed|9537360]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9537360], [protein|search|SigF] [Pubmed|16497325]

Regulation

• expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|16497325]
• expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) ([protein|search|ArsR]) [Pubmed|9537360]

Regulatory mechanism

• [protein|search|ArsR]: transcription repression [Pubmed|9537360]

References

• 16497325,11679756,9537360,17303556,21258851,25494643