gcvPA [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

glycine decarboxylase (subunit 1)

locus: BSU24560

pI: 6.95

mw: 49.00 kDa

function: glycine utilization

product: glycine decarboxylase (subunit 1)

essential: no

ec: 1.4.4.2

synonyms: yqhJ, gcvP

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.8|Utilization of threonine/ glycine]

[SW|Categories] containing this gene/protein

• [SW|utilization of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|Gly-box]

Gene

Coordinates on the chromosome (coding sequence): 2,546,869 -> 2,548,215

The protein

Catalyzed reaction/ biological activity

• Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO₂ (according to Swiss-Prot)

Protein family

• N-terminal subunit subfamily (according to Swiss-Prot)

Expression and Regulation

Operon

• '' [protein|search|gcvT]-[SW|gcvPA]-[SW|gcvPB]'' [Pubmed|15472076]

Regulation

• repressed by casamino acids [Pubmed|12107147]
• induced by glycine [Pubmed|15472076]

Regulatory mechanism

• induction requires a co-operatively acting [SW|riboswitch] ([protein|search|Gly-box]) [Pubmed|15472076]

References

• 12107147,15472076