csaA [Fri Nov 06 2015 10:27:01 GMT+0100 (CET)]

molecular chaperone involved in protein secretion

locus: BSU19040

pI: 8.00

mw: 11.00 kDa

function: protein secretion

product: molecular chaperone

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]

[SW|Categories] containing this gene/protein

• [SW|protein secretion], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence): 2,079,214 -> 2,079,546

Phenotypes of a mutant

• From unsuccessful trials to knock out the gene it was concluded that ''csaA'' apparently is essential. However, in a conditional mutant (Pspac-''csaA''), depletion of the gene product is not lethal. But secretion of some proteins including [protein|search|SdpC] was reported to be affected unter such conditions.[Pubmed|10816431]

The protein

Catalyzed reaction/ biological activity

• Secretion associated chaperone. Assumed functional analogue of ''E. coli'' SecB

Protein family

• FIG1 subfamily (according to Swiss-Prot)

[SW|Domains]

• CsaA contains a tRNA binding domain.

Structure

• [PDB|2NZO]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

[SW|Interactions]

• [protein|search|CsaA]-[protein|search|SdpC] [Pubmed|13129613]
• [protein|search|CsaA]-[protein|search|SecA] [Pubmed|10816431]
• [protein|search|CsaA]-[protein|search|CsaA]

Additional information

• The functional entity of CsaA is the homodimer.

Biological materials

Mutant

• Pspac-csaA [Pubmed|10816431]

References

Reviews

• 25212246

Original publications

• 10816431,13129613,17372352,10658654,10816431,13129613