bioD [Mon Aug 31 2015 13:56:21 GMT+0200 (CEST)]

dethiobiotin synthase

locus: BSU30210

pI: 6.21

mw: 25.00 kDa

function: biosynthesis of biotin

product: dethiobiotin synthase

essential: no

ec: 6.3.3.3

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.1|Biosynthesis/ acquisition of biotin]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

This gene is a member of the following [SW|regulons]

• [SW|BirA regulon]

The protein

Catalyzed reaction/ biological activity

• ATP + 7,8-diaminononanoate + CO₂ = ADP + phosphate + dethiobiotin (according to Swiss-Prot)

Protein family

• dethiobiotin synthetase family (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|bioW]-[protein|search|bioA]-[protein|search|bioF]-[protein|search|bioD]-[protein|search|bioB]-[protein|search|bioI]-[protein|search|ytbQ]'' [Pubmed|8763940,8892842]

Regulation

• repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|8763940,8892842]

Regulatory mechanism

• [protein|search|BirA]: transcription repression [Pubmed|8763940,8892842]

References

Reviews: [Pubmed|21437340]==

Original publications

• 8763940,8892842