putative cysteine ABC transporter (binding protein), the yxeK-snaB-yxeM-yxeN-yxeO-sndB-yxeQ operon may be implicated in the utilization of a modified cysteine variant
function
uptake of cysteine
product
putative cysteine ABC transporter (binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.2|Uptake of amino acids][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.9|Biosynthesis/ acquisition of cysteine][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.4|Sulfur metabolism] → [category|SW 2.6.4.3|Conversion of S-(2-succino)cysteine to cysteine][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CymR regulon]Gene
Coordinates on the chromosome (coding sequence)
4,059,488 -> 4,060,282
The protein
Protein family
bacterial solute-binding protein 3 family (according to Swiss-Prot)[SW|Localization]
associated to the membrane (via [protein|search|YxeN]) [Pubmed|10092453][SW|Interactions]
[protein|search|YxeO]-[protein|search|YxeN]-[protein|search|YxeM] [Pubmed|10092453]Expression and Regulation
Operon
''[protein|search|yxeK]-[protein|search|snaB]-[protein|search|yxeM]-[protein|search|yxeN]-[protein|search|yxeO]-[protein|search|sndB]-[protein|search|yxeQ]'' [Pubmed|10746760][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16513748]Regulation
repressed in the presence of cysteine ([protein|search|CymR]) [Pubmed|16513748]Regulatory mechanism
[protein|search|CymR]: transcription repression [Pubmed|16513748]Additional information
the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y] [PubMed|21815947]Biological materials
Mutant
1A950 ( ''yxeM''::''cat''), [Pubmed|15262924], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A950&Search=1A950 BGSC]References
10092453,12193636,16513748,10746760,21815947 
