tagO

undecaprenyl-phosphate-GlcNAc-1-phosphate transferase, teichoic acid linkage unit synthesis

locus: BSU_35530

pI: 10.42

mw: 39.21 kDa

protein length: 358 aa

gene length: 1077 bp

function: biosynthesis of teichoic acid

product: undecaprenyl-phosphate-GlcNAc-1-phosphate transferase

essential: yes

ec: 2.7.8.33

synonyms: yvhI

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 3,648,654 → 3,649,730

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-α-D-glucosamine --> N-acetyl-α-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP (according to UniProt)

Protein family

• glycosyltransferase 4 family (with [protein|4D3D4429E1F387BACB0D5A1084AA8DF179A16685|MraY], according to UniProt)

Structure

• [PDB|4J72] (from Aquifex aeolicus, 28% identity) [pubmed|23990562]

[SW|Localization]

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|D9257531C2E24426781342314953B89A8272C5E5|tagO]
  description: [Pubmed|22383849]

References

Reviews

• 24024634

Original publications

• 12101296,18156271,23986448,23990562