methionine ABC transporter (ATP-binding protein)
function
methionine uptake
product
methionine ABC transporter (ATP-binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.2|Uptake of amino acids][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|S-box]Gene
Coordinates on the chromosome (coding sequence)
3,363,266 -> 3,364,291
The protein
Structure
[PDB|3DHW] (the [SW|MetN]-[SW|MetP] complex from ''E. coli'', 44% identity) [Pubmed|18621668][SW|Localization]
associated to the cell membrane, via [protein|search|MetP] [Pubmed|10092453,18763711][SW|Interactions]
[protein|search|MetN]-[protein|search|MetP]-[protein|search|MetQ] [Pubmed|10092453]Expression and Regulation
Operon
''[protein|search|metN]-[protein|search|metP]-[protein|search|metQ]'' [Pubmed|10094622]Regulation
activated during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]Regulatory mechanism
[protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622][protein|search|CodY]: transcription activation [Pubmed|12618455]Biological materials
Mutant
1A797 ( ''metN''::''cat''), [Pubmed|14990259], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A797&Search=1A797 BGSC]References
10092453,14990259,12618455,18763711,10094622,18039762,18621668 
