GTPase activating protein, activates FlhF, activates assembly of the flagellar C ring, control of flagellar basal body position
function
activation of FlhF
product
GTPase activating protein
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.4|Motility and chemotaxis/ other][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.4|Swarming][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][SW|Categories] containing this gene/protein
[SW|motility and chemotaxis], [SW|resistance against toxins/ antibiotics]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|DegU regulon], [SW|SigD regulon], [SW|Spo0A regulon]Gene
Phenotypes of a mutant
susceptible to acriflavine and ethidium bromide, and severe growth inhibition as surfactin concentration increased up to 100ug/ml.The protein
Catalyzed reaction/ biological activity
binds [protein|search|FlhF] and stimulates its GTPase activity [Pubmed|22056770]controls the distance between the flagellar bodies [Pubmed|23190039]Protein family
View classification (according to Swiss-Prot)Structure
[PDB|4RZ3] (from ''Geobacillus thermodenitrificans'') [Pubmed|25733861][PDB|3SYN] (complex with [protein|search|FlhF]) [Pubmed|22056770][SW|Localization]
cytoplasm (homogeneous) and flagellar basal body [Pubmed|25733861,16479537][SW|Interactions]
forms homodimers [Pubmed|25733861][protein|search|FlhG]-[protein|search|FlhF] ([protein|search|FlhG] binds the GTP-bound homodimer of [protein|search|FlhF]) [Pubmed|22056770][protein|search|FlhG]-([protein|search|FliY]-[protein|search|FliM])-[protein|search|FliG] [Pubmed|25733861]Expression and Regulation
Operon
part of the [[fla-che operon]]''[protein|search|flgB]-[protein|search|flgC]-[protein|search|fliE]-[protein|search|fliF]-[protein|search|fliG]-[protein|search|fliH]-[protein|search|fliI]-[protein|search|fliJ]-[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|9657996,8157612,15175317]''[protein|search|ylxF]-[protein|search|fliK]-[protein|search|flgD]-[protein|search|flgE]-[protein|search|fliL]-[protein|search|fliM]-[protein|search|fliY]-[protein|search|cheY]-[protein|search|fliZ]-[protein|search|fliP]-[protein|search|fliQ]-[protein|search|fliR]-[protein|search|flhB]-[protein|search|flhA]-[protein|search|flhF]-[protein|search|flhG]-[protein|search|cheB]-[protein|search|cheA]-[protein|search|cheW]-[protein|search|cheC]-[protein|search|cheD]-[protein|search|sigD]-[protein|search|swrB]'' [Pubmed|20233303][SW|Sigma factor]
''[protein|search|flgB]'': [protein|search|SigA] [Pubmed|9657996], [protein|search|SigD] [Pubmed|9657996]''[protein|search|ylxF]'': [protein|search|SigD] [Pubmed|20233303]Regulation
see [[fla-che operon]]Regulatory mechanism
see [[fla-che operon]]References
Reviews
Original Publications
15066026,17850253,14651647,16479537,9657996,8157612,15175317,22056770,23190039,24386445,25733861 
