SubtiBank SubtiBank
yabM
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yabM

may function in a previously observed alternate pathway for peptidoglycan strand synthesis
Locus
BSU_00570
Isoelectric point
9.62
Molecular weight
57.19 kDa
Protein length
532 aa Sequence Blast
Gene length
1599 bp Sequence Blast
Function
alternate pathway for peptidoglycan strand synthesis
Product
unknown
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
  • Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    64,817 → 66,415

    Phenotypes of a mutant

  • Mutants lacking YabM exhibit sensitivity to moenomycin, an antibiotic that blocks peptidoglycan polymerization by class A penicillin-binding proteins PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • may function in a previously observed alternate pathway for peptidoglycan strand synthesis PubMed

    • Protein family

  • Polysaccharide synthase family (according to UniProt)
  • MOP exporter family

    • Paralogous protein(s)

  • MurJ, YkvU, SpoVB

    • Localization

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    Genes
    yabM-yabN-yabO-yabP-yabQ-divIC-yabR
    Description
    PubMed

    Sigma factors

  • SigM: sigma factor, PubMed, in SigM regulon
  • SigE: sigma factor, PubMed, in SigE regulon
  • SigW: sigma factor, PubMed, in SigW regulon
  • SigD: sigma factor, PubMed, in SigD regulon
  • SigX: sigma factor, PubMed, in SigX regulon

    • Regulation

  • expressed during sporulation (SigE) PubMed
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    Biological materials

    Mutant

  • MGNA-B914 (yabM::erm), available at the NBRP B. subtilis, Japan
  • BKE00570 (ΔyabM::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCCAAAAGCTCCTTCCCA, downstream forward: _UP4_AAATTCATGAGAAGGAGAGA
  • BKK00570 (ΔyabM::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCCAAAAGCTCCTTCCCA, downstream forward: _UP4_AAATTCATGAGAAGGAGAGA

    • References

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