cypX [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

cytochrome P450, cyclo-l-leucyl-l-leucyl dipeptide oxidase

locus: BSU35060

pI: 5.00

mw: 45.00 kDa

function: biosynthesis of the extracellular iron chelate pulcherrimin

product: cytochrome P450, cyclo-l-leucyl-l-leucyl dipeptide oxidase

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]

[SW|Categories] containing this gene/protein

• [SW|acquisition of iron], [SW|electron transport/ other], [SW|iron metabolism]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon]
• [SW|PchR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,602,588 -> 3,603,805

The protein

Catalyzed reaction/ biological activity

• implicated in the three-step oxidative transformation of the diketopiperazine cyclo-l-leucyl-l-leucyl into pulcherriminic acid [Pubmed|20690619]

Protein family

• [SW|cytochrome P450] family (according to Swiss-Prot)

Structure

• [PDB|3NC3] [Pubmed|20690619]

Expression and Regulation

Operon

• ''[protein|search|yvmC]-[protein|search|cypX]'' [http://www.liebertonline.com/doi/pdf/10.1089/ind.2006.2.66 Reference]

Regulatory mechanism

• [protein|search|AbrB]: transcription repression [Pubmed|20817675]

References

• 20690619,20817675,4204912,27542896