carbamoyl-phosphate synthetase (catalytic subunit)
function
pyrimidine biosynthesis
product
carbamoyl-phosphate synthetase (catalytic subunit)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|PyrR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,623,736 -> 1,626,951
The protein
Catalyzed reaction/ biological activity
2 ATP L-glutamine HCO3- H2O = 2 ADP phosphate L-glutamate carbamoyl phosphate (according to Swiss-Prot)Protein family
carB family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|CarB]Structure
[PDB|1JDB] (from ''Escherichia coli'', 49% identity, 69% similarity) [Pubmed|10089390][SW|Localization]
membrane [Pubmed|18763711][SW|Interactions]
[SW|PyrAA]-[SW|PyrAB] [Pubmed|12859215]Expression and Regulation
Operon
''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1709162]Regulation
induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]Regulatory mechanism
[protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]References
Reviews
Original publications
8206849,1709162,18763711,10089390,8663035 
